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Daniela Amodei's Journey from OpenAI to Anthropic: Building a $965 Billion AI Powerhouse

By Ramit SethiPublished: Jun 02, 2026
Daniela Amodei's Journey from OpenAI to Anthropic: Building a $965 Billion AI Powerhouse

In a bold move that reshaped the artificial intelligence landscape, Daniela Amodei, a co-founder of Anthropic, embarked on an entrepreneurial journey after her departure from OpenAI. Her decision, initially fraught with uncertainty, has culminated in Anthropic's emergence as a dominant force in the AI sector, achieving a staggering valuation of $965 billion and solidifying its position as the world's most valuable startup.

Amodei recounted her internal struggles regarding the choice to leave OpenAI in late 2020. This departure, which included her brother Dario Amodei and other senior researchers, was not an easy one. She characterized it as a "crazy thing to do" at the time, indicating the significant risks and doubts associated with stepping away from an established and leading AI institution.

A pivotal moment arrived during a conversation with a trusted mentor. Instead of providing direct solutions, the mentor offered profound advice: "You already know what the right answer is." This simple yet powerful statement served as a catalyst, urging Amodei to trust her inner conviction and judgment. This self-reliance was crucial in her decision to forge a new path.

Prior to co-founding Anthropic, Amodei spent approximately three years at OpenAI, where she held key roles as an engineering manager and later as vice president. Her professional background also includes an early position as a founding recruiter at the fintech unicorn Stripe in 2013, following her studies in English literature at the University of California, Santa Cruz. Her estimated net worth is currently $7 billion.

Anthropic, established in 2021, quickly became a significant competitor to OpenAI. The company recently secured $65 billion in a Series H funding round, which propelled its valuation to an astonishing $965 billion, making it the most valuable startup globally. This growth is underpinned by substantial computational infrastructure, including 5 gigawatts of capacity from Amazon and an additional 5 gigawatts of next-generation TPU capacity through partnerships with Google and Broadcom. Furthermore, Anthropic has collaborated with Elon Musk's SpaceX to access GPU resources at its Colossus 1 and Colossus 2 facilities.

On the product development front, Anthropic has introduced Claude Opus 4.8, its latest AI model designed to enhance performance and offer advanced controls for developers and enterprise clients. The company is also spearheading Project Glasswing, an AI security testing initiative involving over 50 organizations. Signaling future ambitions, Anthropic has confidentially filed a draft Form S-1 with the U.S. Securities and Exchange Commission, taking the initial steps towards a potential public listing.

Daniela Amodei's journey exemplifies the power of conviction and strategic vision. From a challenging decision to leave OpenAI to leading Anthropic to unprecedented heights, her story highlights the dynamic and competitive nature of the artificial intelligence industry. The company's rapid expansion, technological advancements, and increasing valuation underscore its significant impact on the global tech landscape.

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